Spermidine is a naturally occurring polyamine found in wheat germ, soybeans, aged cheese, and mushrooms. It has gained attention in the longevity community primarily for its role in inducing autophagy — the cellular process of cleaning up damaged components and recycling them. Observational studies have associated higher dietary spermidine intake with reduced cardiovascular mortality, and early clinical trials are exploring supplemental doses. Spermidine content per capsule is typically low (1–10mg), and wheat germ extract is the most common source. Products below are ranked by cost at your chosen daily dose.
Read our Spermidine price comparison article for tips on what to look for when buying spermidine.
| # | Product | 30-day cost | Supply | Sticker | |
|---|---|---|---|---|---|
| 1 |
Spermidine 3HCL Supplement - 120 10mg Capsules - 3rd Party COA's provided with Every lot# - Spermidine Trihydrochloride
Lab Tested Supplements
|
$4.74 | 120d | $18.95 | View on Amazon |
| 2 |
ProHealth Pure Spermidine 1 mg | 180 Capsules | Plant-Based Wheat Germ Extract for Cellular Renewal & Autophagy Support | Non-GMO, Triple Lab-Tested, GMP-Certified
ProHealth Store
|
$4.99 | 18d | $29.95 | View on Amazon |
| 3 |
Ultimate Spermidine Supplements for Men and Women, 100x Formula, Longevity Supplements Support, 10 mg Per Capsule, 3rd Party Tested, Vegan, 120 Servings
Chemist Labs Store
|
$5.00 | 120d | $19.99 | View on Amazon |
| 4 |
30mg Spermidine Supplement for Men & Women, High Absorption, More Potent Than Spermidine 3HCL - for Cellular Renewal, Longevity & Cognitive, Fermented Wheat Germ Extract, Pure & Natural, 120 Softgels
CORPORALIGHT Store
|
$6.10 | 360d | $24.40 | View on Amazon |
| 5 |
Spermidine Supplement (1440mg of 99% Pure Spermidine Supplements For Women & Men) 4 Months Supply (100X More Potent Than Wheat Germ Extract) 12MGS Per Serving For Cellular Health, Anti-Aging & Energy
Black Forest Store
|
$6.49 | 144d | $25.96 | View on Amazon |
| 6 |
Pure Spermidine Supplement with Trihydrochloride 3HCL 10mg - 120 Capsules
MAXLIFE NATURALS Store
|
$6.74 | 120d | $26.98 | View on Amazon |
| 7 |
Spermidine Supplements for Men and Women–10 mg Spermidine HCl Complex with TMG & Organic Berry Antioxidants–Cellular Health Support–60 Capsules (60-Day Supply) for Healthy Aging & Longevity
eon labs Store
|
$7.48 | 60d | $14.95 | View on Amazon |
| 8 |
Neurogan Spermidine Supplement - 20 mg per Serving | 98% Pure | Autophagy Support & Cellular Health Supplements | Liquid Spermidine 3rd Party Tested | 60 mL, Made in USA
Neurogan Store
|
$7.50 | 240d | $29.99 | View on Amazon |
| 9 |
30mg Spermidine Supplement for Men & Women, High Absorption, More Potent Than Spermidine 3HCL - for Cellular Renewal, Longevity & Cognitive, Fermented Wheat Germ Extract, Pure & Natural, 60 Softgels
CORPORALIGHT Store
|
$8.50 | 180d | $17.00 | View on Amazon |
| 10 |
LongLifeNutri Spermidine 20mg, Supports Cellular Health & Brain Function - 180 Count, 2 Serving Size, Vegan Capsules, Wheat Germ Extract, Naturally Support Wellness, Lab Tested, Crafted in USA
LongLifeNutri Store
|
$8.66 | 180d | $25.97 | View on Amazon |
| 11 |
Spermidine Supplements - 1260mg | Ultra-Pure 99% Spermidine, Made in USA & USA 3rd-Party Tested |100x More Potent, Spermidine Supplements for Women & Men, Longevity Support
CELLOTRICS Store
|
$10.00 | 126d | $29.99 | View on Amazon |
| 12 |
STONERA Spermidine Supplement, Cellular Renewal & Longevity Support - Optimized High Purity, 10mg per Serving, 120 Capsules Third-Party Tested
STONERA Store
|
$11.50 | 60d | $22.99 | View on Amazon |
| 13 |
Force Factor Spermidine Supplements for Women & Men, Antioxidants Supplement for Longevity & Cellular Health, Vegan, No Gelatin, Non-GMO, 120 Capsules
Force Factor Store
|
$12.49 | 60d | $24.98 | View on Amazon |
| 14 |
Shrink Spermidine Supplements Skin & Anti-Aging Support – 120 Vegan Caps 100% Natural Polyamine for Men and Women, Overall Wellness – Non-GMO, USA Made – with High Spermidine, Zinc & Thiamin
shrink Store
|
$12.50 | 60d | $24.99 | View on Amazon |
| 15 |
Spermidine Wheat Germ Extract Capsules - 13mg Spermidine Supplements 1300mg Potent Formula with Higher Spermidine Content and Zinc for Healthy Aging, Daily Immune System and Cell Renewal,4 Pack
Thalacy Store
|
$14.25 | 156d | $56.99 | View on Amazon |
| 16 |
Spermidine Liquid Drops — 99.5% Pure | Double-Potency 40 mg | Cellular Renewal & Healthy Aging Support | Organic Peppermint Flavor | Pure Bioavailable Polyamine Supplement — 2 fl oz
PureWise Store
|
$14.99 | 240d | $29.99 | View on Amazon |
| 17 |
Spermidine Wheat Germ Extract Capsules - 13mg Spermidine Supplements 1300mg Potent Formula with Higher Spermidine Content and Zinc for Healthy Aging, Daily Immune System and Cell Renewal,3 Pack
Thalacy Store
|
$15.00 | 117d | $44.99 | View on Amazon |
| 18 |
Spermidine Supplement (10mg of 99% Spermidine 3HCL - Third Party Tested) 120 Capsules - Over 100x More Potent Than Wheat Germ Extract for Cell Membrane, Telomere Health and Aging by Double Wood
Double Wood Supplements Store
|
$19.97 | 60d | $39.95 | View on Amazon |
| 19 |
Spermidine Supplements 13mg - 1300mg Wheat Germ Extract Capsules Potent Formula with Higher Spermidine Content and Zinc for Healthy Aging, Daily Immune System and Cell Renewal, 60 Capsules
Thalacy Store
|
$19.99 | 39d | $19.99 | View on Amazon |
| 20 |
Prime Powders Spermidine Capsules Gluten Free 99% Concentration 100x More Potent Than Wheat Germ Extract for Anti-Aging DNA Telomere Support
Prime Powders
|
$20.00 | 60d | $39.99 | View on Amazon |
| 21 |
partiQlar Spermidine Supplements for Men & Women - 10mg Longevity - 60 Caps
partiQlar Store
|
$20.00 | 48d | $39.99 | View on Amazon |
| 22 |
Spermidine Supplement 15 MG - 99% Purity, High Absorption, 1500 MG Fermented Wheat Germ Extract with Zinc & Thiamin, Spermidine for Men & Women - Cellular Renewal, Aging Defense, Energy, 60 Softgels
Sohahila Store
|
$21.39 | 45d | $21.39 | View on Amazon |
| 23 |
Spermidine Supplement Standardized to 99% Spermidine Trihydrochloride | Ultra High Strength. More Potent Than Wheat Germ Extract. Vegan Capsules for Healthy Aging, Longevity. USA Tested Supplements
Peak Performance Store
|
$21.95 | 30d | $21.95 | View on Amazon |
| 24 |
Toniiq Ultra Concentrated 500mg Spermidine Supplements for Men and Women - Non-Synthetic Spermidine Standardized to No Less Than 1% - 5mg per Serving Rice Germ Extract
Toniiq
|
$22.21 | 30d | $44.41 | View on Amazon |
| 25 |
BIGVITA Yuth Gummies + | High-Purity Spermidine Supplement for Cellular Renewal & Anti-Aging | Collagen Support with Vitamin C & A (60 Gummies - Bottle)
BIGVITA Store
|
$22.98 | 18d | $45.96 | View on Amazon |
| 26 |
Amen Spermidine, Trihydrochloride, Vitamin C, Vegan, 30 Capsules | Spermidine 10 mg with vitamin C, one capsule per serving. Gluten-free, vegan, non-GMO.
Amen Store
|
$24.99 | 30d | $24.99 | View on Amazon |
| 27 |
Enhanced Absorption Pure Spermidine Supplement - 99% Standardized Spermidine 3HCL Anti Aging Supplement for Women and Men’s Longevity Brain Telomere Heart Cell and Skin Support - 60 Servings
Vitauthority Store
|
$29.99 | 30d | $29.99 | View on Amazon |
| 28 |
Spermidine Supplement – 120 Vegetable Capsules – Wheat Germ Extract with 1000 mg Spermidine, Enhanced with BioPerine for Optimal Absorption (2-Pack)
The Supermom Company Store
|
$29.99 | 60d | $59.97 | View on Amazon |
| 29 |
Spermidine Supplement 15 MG - 99% Purity, High Absorption, 1500 MG Fermented Wheat Germ Extract with Zinc & Thiamin, Spermidine for Men & Women - Cellular Renewal, Aging Defense, Energy, 120 Softgels
Sohahila Store
|
$31.39 | 45d | $31.39 | View on Amazon |
| 30 |
Renue By Science Spermidine Supplements | Liposomal Spermidine Supplements for Women and Men | 90 Capsules - 8mg Spermidine per Serving | Non-GMO & Allergen Free | Made in the USA Third-Party Tested
Renue By Science Store
|
$33.30 | 36d | $49.95 | View on Amazon |
| 31 |
Nutricost Spermidine Wheat Germ Extract Supplement 120 Capsules for 40 Servings Per Bottle - Vegetarian, GMO Free
Nutricost Store
|
$33.71 | 60d | $44.95 | View on Amazon |
| 32 |
OMRE Spermidine Supplement (10mg of Non-Synthetic Spermidine) - 3rd-Party Tested 1000mg Wheat Germ Extract Standardized to No Less Than 1% - 10mg of Natural Spermidine per Serving
OMRE Store
|
$54.00 | 30d | $54.00 | View on Amazon |
| 33 |
Codeage Liposomal Spermidine NAD+ Spermidine Supplement - 500 Mg NAD+ Vitamin C - Liposomal Delivery - Nicotinamide Adenine Dinucleotide Pills - 1 Capsule Per Serving - Vegan, Non-GMO - 30 Capsules
Codeage Store
|
$76.95 | 30d | $76.95 | View on Amazon |
| 34 |
Spermidine Wheat Germ Extract Capsules - 13mg Spermidine Supplements 1300mg Potent Formula with Higher Spermidine Content and Zinc for Healthy Aging, Daily Immune System and Cell Renewal,6 Pack
Thalacy Store
|
$81.99 | 39d | $81.99 | View on Amazon |
This is the current ranking surface for Spermidine. It recalculates cost per month from product price, Supplement Facts active amount, servings per container, and the dose you enter above.
35 active products have enough price and label data to calculate cost before display filters; 34 rows are currently shown in the ranked table. The current review floor for this category is 25+ reviews before any large-category and duplicate/bulk filtering.
At 10 mg/day, visible products range from $4.74-$81.99/mo with a $17.48/mo median midpoint and a 17.3x low-to-high spread.
Look for the actual spermidine amount, not only wheat germ extract or a high extract weight. Labels reviewed for this update included wheat germ extract products, spermidine trihydrochloride-style labels, and longevity blends with additional polyphenols or vitamins.
Monthly cost depends heavily on the delivered spermidine amount, extract standardization, capsule count, and branded longevity positioning. A large extract amount can still deliver only a small spermidine dose.
Do not treat wheat germ extract weight as spermidine unless the label gives a spermidine standardization or amount. Also separate standalone spermidine from anti-aging blends where other ingredients may be driving the price.
Spermidine has emerging evidence around autophagy, cardiovascular markers, and early clinical interest. TrueServing compares labeled spermidine cost at 10 mg/day and does not validate longevity claims.
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