5-HTP, short for 5-hydroxytryptophan, is a serotonin precursor most often sold for mood, sleep, and appetite support. Most standalone products provide 100 mg per capsule, with many labels suggesting one to two capsules per day, so TrueServing compares products at a 200 mg daily reference dose. The evidence is best described as emerging: 5-HTP has human research, especially around mood, but the study base is mixed and often older or small. It is also one of the categories where safety context matters because 5-HTP can interact with antidepressants and other serotonergic drugs. When comparing products, look for labels that state the actual 5-HTP amount, not only a raw Griffonia simplicifolia extract weight. Products below are ranked by cost at your chosen daily dose.
Read our 5-HTP price comparison article for tips on what to look for when buying 5-htp.
| # | Product | 30-day cost | Supply | Sticker | |
|---|---|---|---|---|---|
| 1 |
BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, Mood Support Supplement - Gluten Free, 1 Capsule per Serving (50mg), 365 Capsules (Pack of 1)
BulkSupplements Store
|
$1.72 | 91d | $20.97 | View on Amazon |
| 2 |
BulkSupplements.com 5-HTP Powder - 5-Hydroxytryptophan, Mood Support Supplement - Gluten Free, 200mg per Serving, 100g (3.5 oz) (Pack of 1)
BulkSupplements Store
|
$1.74 | 500d | $28.97 | View on Amazon |
| 3 |
BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, Mood Support Supplement - Gluten Free, 1 Capsule per Serving (200mg), 365 Capsules (Pack of 1)
BulkSupplements Store
|
$2.22 | 365d | $26.97 | View on Amazon |
| 4 |
Best Naturals 5-HTP 50 mg 120 Capsules, 5 HTP Capsules Supports Relaxation & restful Sleep
Best Naturals Store
|
$2.25 | 30d | $8.99 | View on Amazon |
| 5 |
Nutricost 5-HTP 100mg, 240 Vegetarian Capsules (5-Hydroxytryptophan) - Non-GMO & Gluten Free
Nutricost Store
|
$2.49 | 120d | $19.95 | View on Amazon |
| 6 |
Amazing Formulas 5-HTP (Hydroxytryptophan) Supplement | 100 Mg Per Serving | Veggie Capsules | Non-GMO | Gluten Free | Made in USA (1 Pack, 120 Count)
Amazing Nutrition Store
|
$2.50 | 60d | $9.99 | View on Amazon |
| 7 |
BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, Mood Support Supplement - Gluten Free, 1 Capsule per Serving (100mg), 240 Capsules (Pack of 1)
BulkSupplements Store
|
$2.62 | 120d | $20.97 | View on Amazon |
| 8 |
NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 50 mg, Neurotransmitter Support*, 180 Veg Capsules
NOW Foods Store
|
$3.08 | 45d | $18.49 | View on Amazon |
| 9 |
NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 50 mg, Neurotransmitter Support*, 90 Veg Capsules
NOW Foods Store
|
$3.67 | 23d | $11.01 | View on Amazon |
| 10 |
Doctors Best 5-HTP 100mg Capsules - Vegan 5HTP Supplement for Women & Men, Supports Mental & Emotional Well-Being for Adults, Non-GMO, Gluten Free, Soy Free - 180 Veg Caps
Doctor's BEST Store
|
$3.83 | 90d | $22.99 | View on Amazon |
| 11 |
Amazing Formulas 5-HTP (L-5-Hydroxytryptophan) Supplement | 200 Mg per Serving | Veggie Capsules | Non-GMO | Gluten-Free | Made in USA (1 Pack | 120 Count)
Amazing Nutrition Store
|
$4.00 | 120d | $15.99 | View on Amazon |
| 12 |
NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 240 Veg Capsules
NOW Foods Store
|
$4.00 | 120d | $31.99 | View on Amazon |
| 13 |
NOW Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 120 Veg Capsules
NOW Foods Store
|
$4.20 | 60d | $16.79 | View on Amazon |
| 14 |
Primaforce 5-HTP 100mg Supplement, 120 Capsules, 100mg Per Serving, 5-Hydroxytryptophan
Primaforce Store
|
$4.24 | 60d | $16.94 | View on Amazon |
| 15 |
Nutricost 5-HTP 200mg, 120 Vegetarian Capsules (5-Hydroxytryptophan) - Non-GMO & Gluten Free
Nutricost Store
|
$4.24 | 120d | $16.94 | View on Amazon |
| 16 |
Doctors Best 5-HTP Enhanced with Vitamins B6 & C - Vegan 5 HTP Supplement for Women & Men, Supports Mental & Emotional Well-Being for Adults, Non-GMO, Gluten Free, Soy Free - 120 Veg Caps
Doctor's BEST Store
|
$4.25 | 60d | $16.99 | View on Amazon |
| 17 |
BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, Mood Support Supplement - Gluten Free, 2 Capsules per Serving (400mg), 360 Capsules (Pack of 1)
BulkSupplements Store
|
$4.49 | 360d | $26.97 | View on Amazon |
| 18 |
BulkSupplements.com 5-HTP Powder - 5-Hydroxytryptophan, Mood Support Supplement - Gluten Free, 200mg per Serving, 25g (0.88 oz) (Pack of 1)
BulkSupplements Store
|
$4.55 | 125d | $18.97 | View on Amazon |
| 19 |
5-HTP Supplement - 200mg per Serving - Extra Strength 5HTP from Griffonia Simplicifolia - Supports Restful Sleep, Natural Calm & Brain Health - 5 Hydroxytryptophan - Bottled in USA - 120 Capsules
Nature's Nutrition Store
|
$4.81 | 60d | $9.62 | View on Amazon |
| 20 |
NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 50 mg, Neurotransmitter Support*, 30 Veg Capsules
NOW Foods Store
|
$4.88 | 8d | $4.88 | View on Amazon |
| 21 |
5-HTP Supplement - Extra Strength 5HTP (5-Hydroxytryptophan) Griffonia Simplicifolia 200mg Per Serving - 5HTP Supports Restful Sleep, Natural Calm, & Brain Health - Bottled in the USA - 120 Capsules
Nature's Peak Store
|
$4.91 | 60d | $9.82 | View on Amazon |
| 22 |
Horbäach 5HTP 200mg Supplement | 180 Capsules | 5 Hydroxytryptophan | Griffonia Simplicifolia | Extra Strength | Non-GMO, Gluten Free
Horbäach Store
|
$5.09 | 90d | $15.28 | View on Amazon |
| 23 |
NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 60 Veg Capsules
NOW Foods Store
|
$5.20 | 30d | $10.40 | View on Amazon |
| 24 |
Nutricost 5-HTP Powder 25 Grams (300mg Per Serving) - Gluten Free & Non-GMO, Pure 5-htp
Nutricost Store
|
$5.77 | 125d | $15.95 | View on Amazon |
| 25 |
Now Foods 5-HTP 200 mg 120 VegCap
NOW Foods Store
|
$6.75 | 120d | $27.00 | View on Amazon |
| 26 |
5-HTP Supplement - Extra Strength 5HTP (5-Hydroxytryptophan) Griffonia Simplicifolia 200mg Per Serving - 5HTP Supports Restful Sleep, Natural Calm, & Brain Health - Bottled in the USA - 60 Capsules
Nature's Peak Store
|
$6.82 | 30d | $6.82 | View on Amazon |
| 27 |
Fito Medics 5-HTP Supplement 400 mg – 120 Capsules – Mood & Relaxation Support – Non-GMO Ingredients
FITO MEDIC'S Store
|
$7.00 | 120d | $13.99 | View on Amazon |
| 28 |
Natrol 5-HTP 100mg, Dietary Supplement Helps Support a Balanced Mood, Mood and Stress Support Supplement, 90 Time Release Tablets, 45-90 Day Supply
Natrol Store
|
$7.14 | 45d | $21.42 | View on Amazon |
| 29 |
NOW Supplements, 5-HTP (5-hydroxytryptophan) 200 mg, Double Strength, Neurotransmitter Support*, 120 Veg Capsules
NOW Foods Store
|
$7.34 | 120d | $29.38 | View on Amazon |
| 30 |
Natrol 5-HTP 100 mg Time Release, Helps Support a Balanced Mood, 90 Tablets
Natrol Store
|
$7.65 | 23d | $11.48 | View on Amazon |
| 31 |
Source Naturals Serene Science 5-HTP 200 mg - 60 Capsules
Source Naturals Store
|
$8.03 | 60d | $16.07 | View on Amazon |
| 32 |
Toniiq Ultra High Strength 5HTP Capsules - 99%+ Highly Purified and Bioavailable - 12:1 Concentrated Extract - 200mg - 90 Veggie Capsules
Toniiq
|
$8.32 | 90d | $24.97 | View on Amazon |
| 33 |
Solgar 5-HTP 100 mg, 90 Vegetable Capsules - Promotes Relaxation - Positive Mood & Stress Support - Non-GMO, Vegan, Gluten Free, Dairy Free, Kosher - 90 Servings
Solgar Store
|
$8.50 | 45d | $25.49 | View on Amazon |
| 34 |
Nature's Bounty 5-HTP Pills and Dietary Supplement, Supports a Calm and Relaxed Mood, 100mg, 60 Capsules
Nature's Bounty Store
|
$8.50 | 30d | $16.99 | View on Amazon |
| 35 |
5 Hydroxytryptophan Capsules - 180mg per Serving 5 HTP Supplement Plus Calcium for Brain Health & Sleep Support, Extra Strength Griffonia Simplicifolia 5-HTP Formula, 5HTP, USA Bottled - 60 Capsules
Nature's Nutrition Store
|
$8.92 | 27d | $8.92 | View on Amazon |
| 36 |
Superior Source 5-HTP 75 mg - Natural Supplement Aids Restful Sleep & Neurotransmitter Functions - Brain Health & Function Support - 5-Hydroxytryptophan Supplement - 60 Instant Dissolve Tablets
Superior Source Store
|
$8.99 | 23d | $17.99 | View on Amazon |
| 37 |
NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 200 mg, Double Strength, Neurotransmitter Support*, 60 Veg Capsules
NOW Foods Store
|
$9.18 | 60d | $18.36 | View on Amazon |
| 38 |
Horbäach 5HTP 400mg Capsules | 120 Count | Extra Strength Supplement | Non-GMO, Gluten Free | 5 Hydroxytryptophan
Horbäach Store
|
$9.29 | 120d | $18.59 | View on Amazon |
| 39 |
5-HTP Gummies 200mg with Same & Vitamin B6 – Sugar Free for Sleep, Mood & Relaxation Support – Non-GMO, Gluten Free, 3rd Party Tested – Raspberry Flavor – 60 Count
FUYUEO
|
$10.00 | 60d | $19.99 | View on Amazon |
| 40 |
Allergy Research Group ARG 5-HTP 50-50 mg 5-Hydroxytryptophan - Mindset, Sleep & Appetite Regulation Support - Griffonia Simplicifolia Extract - Vegetarian Capsules - 150 Servings - 150 Capsules
Allergy Research Group Store
|
$10.08 | 38d | $50.39 | View on Amazon |
| 41 |
5-HTP 200 MG Per Serving Plus Calcium for Mood, Sleep – Supports Calm and Relaxed Mood – 99% High Purity – 120 Capsules – Arazo Nutrition
Arazo Nutrition Store
|
$10.48 | 60d | $20.95 | View on Amazon |
| 42 |
Metabolic Maintenance 5-HTP - Delivers 100 mg 5-Hydroxytryptophan - Supports Serotonin Pathways, a Positive Outlook & Restfuness - 120 Servings - 120 Capsules
Metabolic Maintenance Store
|
$11.50 | 60d | $46.00 | View on Amazon |
| 43 |
Nature's Truth 5HTP 200mg Capsules | 50 Count | 5 Hydroxytryptophan | Non-GMO & Gluten Free Supplement
Nature's Truth Store
|
$11.52 | 25d | $9.60 | View on Amazon |
| 44 |
Integrative Therapeutics 5-HTP - Supplement that Supports a Healthy Outlook & Restful Sleep* - Vegan, Dairy-Free & Gluten-Free - 60 Capsules (60 Servings)
Integrative Therapeutics Store
|
$12.00 | 15d | $24.00 | View on Amazon |
| 45 |
Designs for Health 5-HTP 50mg with Vitamin B6 (P-5-P) - 5-HTP Synergy 50 mg Supplement - Serotonin Precursors to Help Support Healthy Mood + Appetite (90 Capsules)
Designs for Health Store
|
$14.50 | 23d | $43.49 | View on Amazon |
| 46 |
Natrol 5-HTP 200 mg Time Release, Helps Support a Balanced Mood, 30 Tablets
Natrol Store
|
$14.99 | 30d | $14.99 | View on Amazon |
| 47 |
Vitamatic Sugar Free 5-HTP 200mg Gummies with B6 – 60 Pectin-Based Gummies – Mood Support & Stress Relief
Vitamatic Store
|
$14.99 | 30d | $14.99 | View on Amazon |
| 48 |
Natrol 5-HTP 100 mg Fast Dissolve, 30 Mixed Berry Tablets
Natrol Store
|
$15.19 | 15d | $15.19 | View on Amazon |
| 49 |
BeLive 5-HTP Gummies – 2 Pack - 120 Ct I 5HTP Calming Gummies for Heightened Focus, Relaxation & Rest for Adults | Vegan - Mixed Berries Flavor
BeLive Store
|
$16.85 | 46d | $33.70 | View on Amazon |
| 50 |
BeLive 5-HTP Gummies - 60 Ct I 5HTP Stress Relief Gummies for Better Sleep, Heightened Focus, Mood Booster & Stress Relief I Serotonin Booster for Adults, Vegan 5 HTP Supplement - Mixed Berries Flavor
BeLive Store
|
$18.11 | 23d | $18.11 | View on Amazon |
| 51 |
Vital Nutrients 5-HTP 50mg (5-hydroxytryptophan) - Vegan Serotonin Support Supplement* - Sleep and Stress Support - 5HTP and Vitamin B6 - Gluten, Dairy, Soy Free - Non-GMO - 60 Capsules
Vital Nutrients Store
|
$18.50 | 15d | $36.99 | View on Amazon |
| 52 |
DR. EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e for Mood, Stress, and Sleep - 5HTP Supplement with Vitamin B6-120 Vegan Capsules, 60 Servings
DR. EMIL NUTRITION Store
|
$18.80 | 60d | $37.60 | View on Amazon |
| 53 |
Nature's Way 5-HTP, L-5-Hydroxytryptophan, Helps Make Serotonin to Promote a Positive Outlook*, Vitamin B6, Vitamin C, Griffonia Bean Extract, 30 Tablets (Packaging May Vary)
Nature's Way Store
|
$19.78 | 8d | $9.89 | View on Amazon |
| 54 |
Irwin Naturals Double Potency 5-HTP Extra - Relaxation & Serotonin Support - 60 Liquid Soft-Gels - 2 Pack
Irwin Naturals Store
|
$19.97 | 30d | $39.93 | View on Amazon |
| 55 |
Irwin Naturals Double Potency 5-HTP Extra - Relaxation & Serotonin Support - 60 Liquid Soft-Gels
Irwin Naturals Store
|
$19.99 | 15d | $19.99 | View on Amazon |
| 56 |
Natrol 5-HTP 200 mg Time Release, Helps Support a Balanced Mood, 60 Tablets
Natrol Store
|
$21.66 | 60d | $43.32 | View on Amazon |
| 57 |
5-HTP - 200mg 5HTP Supplement (5-Hydroxytryptophan) to Support Mood Plus Sleep*, Stress Relief*, 60 Capsules - 30 Day Supply, Made in USA
Valleywave Labs
|
$24.50 | 30d | $24.50 | View on Amazon |
| 58 |
Vimergy 5-HTP Capsules– Clean Formula Supporting a Healthy Mood, Better Sleep and May Enhance Serotonin Levels.* Kosher and Vegan. – (60 ct.)
Vimergy Store
|
$25.50 | 45d | $51.00 | View on Amazon |
| 59 |
THORNE - 5-HTP - Contains Vitamin B6 - Serotonin Support for Sleep & Stress Management* - 5-Hydroxytryptophan Supplement - Third-Party Certified - Gluten, Dairy & Soy-Free - 90 Capsules
THORNE Store
|
$26.00 | 23d | $39.00 | View on Amazon |
| 60 |
Designs for Health 5-HTP 100mg with Vitamin B6 (P-5-P) - 5-HTP Supreme 100 mg Supplement - Serotonin Precursors to Help Support Healthy Mood + Appetite (60 Capsules)
Designs for Health Store
|
$26.50 | 30d | $52.99 | View on Amazon |
| 61 |
Product gallery
Visit the SmarterVitamins Store
|
$29.77 | 30d | $29.77 | View on Amazon |
| 62 |
Pure Encapsulations 5-HTP 100 mg - Brain Health, Sleep Regulation & Appetite Support* - 5-Hydroxytryptophan - Gluten Free & Non-GMO - 60 Capsules
Pure Encapsulations Store
|
$30.50 | 30d | $61.00 | View on Amazon |
This is the current ranking surface for 5-HTP. It recalculates cost per month from product price, Supplement Facts active amount, servings per container, and the dose you enter above.
65 active products have enough price and label data to calculate cost before display filters; 62 rows are currently shown in the ranked table. The current review floor for this category is 25+ reviews before any large-category and duplicate/bulk filtering.
At 200 mg/day, visible products range from $1.72-$30.50/mo with a $8.18/mo median midpoint and a 17.7x low-to-high spread.
Check whether the label lists direct 5-HTP, 5-hydroxytryptophan, Griffonia simplicifolia seed extract, or a percentage-standardized extract. Labels reviewed for this update included clear 100-200 mg 5-HTP capsules, powders requiring a milligram scale, and one ambiguous 10% 200 mg 5-HTP line with added vitamin B6 and SAMe.
Monthly cost depends on the actual 5-HTP amount, powder versus capsule format, serving count, and whether the product is plain or bundled with mood/sleep cofactors. Bulk powder can be very cheap but adds measurement friction; premium low-dose capsules can be much more expensive.
Do not treat a percent-standardized extract line as the same as a plainly listed 5-HTP amount unless the label makes the math clear. For powders, the label-reviewed products explicitly required an accurate milligram scale, so convenience and dosing precision matter alongside price.
5-HTP has emerging evidence for mood and sleep-related outcomes, but much of the clinical literature is older, small, or heterogeneous. TrueServing compares labeled 5-HTP cost at 200 mg/day; serotonin-pathway interactions and safety warnings matter more than chasing the cheapest option.
TrueServing participates in the Amazon Associates program. We may earn a commission when you purchase through our links at no extra cost to you. Prices are updated regularly but may vary.