5-HTP, ranked by real cost

Typical dose: 100-300mg/day
Used for: Mood support, sleep support, appetite support, serotonin precursor
Evidence: Emerging - 5-HTP has human research for depression and sleep-related outcomes, but much of the clinical evidence is older, small, heterogeneous, or not strongly placebo-controlled. Safety and interaction warnings matter because 5-HTP affects serotonin pathways.

5-HTP, short for 5-hydroxytryptophan, is a serotonin precursor most often sold for mood, sleep, and appetite support. Most standalone products provide 100 mg per capsule, with many labels suggesting one to two capsules per day, so TrueServing compares products at a 200 mg daily reference dose. The evidence is best described as emerging: 5-HTP has human research, especially around mood, but the study base is mixed and often older or small. It is also one of the categories where safety context matters because 5-HTP can interact with antidepressants and other serotonergic drugs. When comparing products, look for labels that state the actual 5-HTP amount, not only a raw Griffonia simplicifolia extract weight. Products below are ranked by cost at your chosen daily dose.

Read our 5-HTP price comparison guide for tips on what to look for when buying 5-htp.

Daily dose (mg) 3rd-party tested Certificate of Analysis 100+ reviews

66 products

#	Product	30-day cost	Supply	Sticker
1	BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, 5-HTP 50mg - 5 HTP Supplement for Well-Being - Amino Acid & Gluten Free, 1 Capsule per Serving, 365 Capsules (Pack of 1) BulkSupplements Store CapsulesFew reviews	$1.64	91d	$19.97	View on Amazon
2	BulkSupplements.com 5-HTP Powder - 5-Hydroxytryptophan, 5 HTP Supplement - 5-HTP 200mg, Mood Support Supplement - Gluten Free, 200mg per Serving, 100g (3.5 oz) (Pack of 1) BulkSupplements Store Powder	$1.68	500d	$27.97	View on Amazon
3	BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, 5-HTP 200mg, 5 HTP Supplement - Amino Acid Supplement, Gluten Free, 1 Capsule per Serving, 365 Capsules (Pack of 1) BulkSupplements Store Capsules	$2.13	365d	$25.97	View on Amazon
4	Best Naturals 5-HTP 50 mg 120 Capsules, 5 HTP Capsules Supports Relaxation & restful Sleep Best Naturals Store Capsules	$2.25	30d	$8.99	View on Amazon
5	Best Naturals 2 Packs 5-HTP (5-hydroxytryptophan) 100 mg 120 Capsules Best Naturals Store Capsules	$2.37	120d	$18.99	View on Amazon
6	Nature's Trove 5-HTP 100mg 120 Vegetarian Capsules Nature's Trove Store Capsules3rd-party tested	$2.47	60d	$9.89	View on Amazon
7	Amazing Formulas 5-HTP (Hydroxytryptophan) Supplement \| 100 Mg Per Serving \| Veggie Capsules \| Non-GMO \| Gluten Free \| Made in USA (1 Pack, 120 Count) Amazing Nutrition Store Capsules	$2.50	60d	$9.99	View on Amazon
8	BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, Amino Acid Supplement - Gluten Free, 1 Capsule per Serving, 240 Count (Pack of 1) BulkSupplements Store Capsules	$2.50	120d	$19.97	View on Amazon
9	NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 50 mg, Neurotransmitter Support*, 180 Veg Capsules NOW Foods Store Capsules	$3.08	45d	$18.49	View on Amazon
10	Primaforce 5-HTP 100mg Supplement, 120 Capsules, 100mg Per Serving, 5-Hydroxytryptophan Primaforce Store Capsules	$3.25	60d	$12.99	View on Amazon
11	NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 50 mg, Neurotransmitter Support*, 90 Veg Capsules NOW Foods Store Capsules	$3.47	23d	$10.40	View on Amazon
12	NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 240 Veg Capsules NOW Foods Store Capsules	$4.00	120d	$31.99	View on Amazon
13	Amazing Formulas 5-HTP (L-5-Hydroxytryptophan) Supplement \| 200 Mg per Serving \| Veggie Capsules \| Non-GMO \| Gluten-Free \| Made in USA (1 Pack \| 120 Count) Amazing Nutrition Store Capsules	$4.00	120d	$15.99	View on Amazon
14	NOW Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 120 Veg Capsules NOW Foods Store Capsules	$4.20	60d	$16.79	View on Amazon
15	Best Naturals 5-HTP 200 mg 120 Vegetarian Capsules Best Naturals Store Capsules	$4.25	120d	$16.99	View on Amazon
16	BulkSupplements.com 5-HTP Powder - 5-Hydroxytryptophan, 5 HTP Supplement - 5-HTP 200mg, Mood Support Supplement - Gluten Free, 200mg per Serving, 25g (0.88 oz) (Pack of 1) BulkSupplements Store Powder	$4.31	125d	$17.97	View on Amazon
17	BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, 5 HTP Supplement - 5-HTP 400mg, for Overall Well-Being - Gluten Free, 2 Capsules per Serving, 360 Count (Pack of 1) BulkSupplements Store Capsules	$4.33	360d	$25.97	View on Amazon
18	NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 50 mg, Neurotransmitter Support*, 30 Veg Capsules NOW Foods Store Capsules	$4.70	8d	$4.70	View on Amazon
19	BulkSupplements.com 5-HTP Capsules - 5-Hydroxytryptophan, 5-HTP 200mg, 5 HTP Supplement - Amino Acid Supplement, Gluten Free, 1 Capsule per Serving, 120 Capsules (Pack of 1) BulkSupplements Store Capsules	$4.74	120d	$18.97	View on Amazon
20	Nature's Bounty 5-HTP Pills and Dietary Supplement, Supports a Calm and Relaxed Mood, 100mg, 60 Capsules Nature's Bounty Store Capsules	$4.91	30d	$9.83	View on Amazon
21	5-HTP Supplement - 200mg per Serving - Extra Strength 5HTP from Griffonia Simplicifolia - Supports Restful Sleep, Natural Calm & Brain Health - 5 Hydroxytryptophan - Bottled in USA - 120 Capsules Nature's Nutrition Store Capsules3rd-party testedFew reviews	$4.91	60d	$9.82	View on Amazon
22	NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 100 mg, Neurotransmitter Support*, 60 Veg Capsules NOW Foods Store Capsules	$4.95	30d	$9.90	View on Amazon
23	Bronson 5-HTP 200mg (5-hydroxytryptophan) Griffonia Simplicifolia Non-GMO, 60 Vegetarian Capsules Bronson Store Capsules	$5.00	60d	$9.99	View on Amazon
24	Horbäach 5HTP 200mg Supplement \| 180 Capsules \| 5 Hydroxytryptophan \| Griffonia Simplicifolia \| Extra Strength \| Non-GMO, Gluten Free Horbäach Store Capsules	$5.09	90d	$15.28	View on Amazon
25	Nutricost 5-HTP Powder 25 Grams (300mg Per Serving) - Gluten Free & Non-GMO, Pure 5-htp Nutricost Store Powder3rd-party tested	$5.77	125d	$15.95	View on Amazon
26	Natrol 5-HTP 100mg, Dietary Supplement Helps Support a Balanced Mood, Mood and Stress Support Supplement, 90 Time Release Tablets, 45-90 Day Supply Natrol Store Tablets	$6.97	45d	$20.90	View on Amazon
27	Fito Medics 5-HTP Supplement 400 mg – 120 Capsules – Mood & Relaxation Support – Non-GMO Ingredients FITO MEDIC'S Store CapsulesFew reviews	$7.00	120d	$13.99	View on Amazon
28	Now Foods 5-HTP 200 mg 120 VegCap NOW Foods Store Capsules	$7.10	120d	$28.40	View on Amazon
29	5-HTP Supplement - 5-HTP 200mg Per Serving - Extra Strength 5HTP (5-Hydroxytryptophan) Griffonia Simplicifolia - Supports Restful Sleep, Natural Calm & Brain Health - Bottled in USA - 60 Capsules Nature's Peak Store Capsules3rd-party testedFew reviews	$7.82	30d	$7.82	View on Amazon
30	NOW Supplements, 5-HTP (5-hydroxytryptophan) 200 mg, Double Strength, Neurotransmitter Support*, 120 Veg Capsules NOW Foods Store Capsules	$7.96	120d	$31.82	View on Amazon
31	5 Hydroxytryptophan Capsules - 200mg per Serving 5 HTP Supplement Plus Calcium for Brain Health & Sleep Support, Extra Strength Griffonia Simplicifolia 5-HTP Formula, 5HTP, USA Bottled - 120 Capsules Nature's Nutrition Store Capsules	$8.26	60d	$16.52	View on Amazon
32	Toniiq Ultra High Strength 5HTP Capsules - 99%+ Highly Purified and Bioavailable - 12:1 Concentrated Extract - 200mg - 90 Veggie Capsules Toniiq Capsules	$8.32	90d	$24.97	View on Amazon
33	Solgar 5-HTP 100 mg, 90 Vegetable Capsules - Promotes Relaxation - Positive Mood & Stress Support - Non-GMO, Vegan, Gluten Free, Dairy Free, Kosher - 90 Servings Solgar Store Capsules	$8.50	45d	$25.49	View on Amazon
34	NOW Foods Supplements, 5-HTP (5-hydroxytryptophan) 200 mg, Double Strength, Neurotransmitter Support*, 60 Veg Capsules NOW Foods Store Capsules	$8.70	60d	$17.40	View on Amazon
35	5 Hydroxytryptophan Capsules - 180mg per Serving 5 HTP Supplement Plus Calcium for Brain Health & Sleep Support, Extra Strength Griffonia Simplicifolia 5-HTP Formula, 5HTP, USA Bottled - 60 Capsules Nature's Nutrition Store Capsules	$8.82	27d	$8.82	View on Amazon
36	Horbäach 5HTP 400mg Capsules \| 120 Count \| Extra Strength Supplement \| Non-GMO, Gluten Free \| 5 Hydroxytryptophan Horbäach Store Capsules	$9.29	120d	$18.59	View on Amazon
37	Nature's Way 5-HTP, L-5-Hydroxytryptophan, Helps Make Serotonin to Promote a Positive Outlook*, Vitamin B6, Vitamin C, Griffonia Bean Extract, 60 Tablets (Packaging May Vary) Nature's Way Store Tablets	$9.43	15d	$9.43	View on Amazon
38	NatureWise 5-HTP 200mg Supplement from Griffonia Seeds with Cofactor Vitamin B6 - Mood Support and Natural Sleep Aid for Adults - Delayed-Release, Vegan - 60 Count[2-Month Supply] NatureWise Store Capsules3rd-party tested	$10.00	60d	$19.99	View on Amazon
39	Allergy Research Group ARG 5-HTP 50-50 mg 5-Hydroxytryptophan - Mindset, Sleep & Appetite Regulation Support - Griffonia Simplicifolia Extract - Vegetarian Capsules - 150 Servings - 150 Capsules Allergy Research Group Store CapsulesFew reviews	$10.08	38d	$50.39	View on Amazon
40	5-HTP 200 MG Per Serving Plus Calcium for Mood, Sleep – Supports Calm and Relaxed Mood – 99% High Purity – 120 Capsules – Arazo Nutrition Arazo Nutrition Store Capsules	$10.48	60d	$20.95	View on Amazon
41	Jarrow Formulas® 5-HTP, 100 mg, Serotonin Precursor, 60 Veggie Capsules, 60 Day Supply Jarrow Formulas Store Capsules	$10.92	30d	$21.84	View on Amazon
42	Superior Source 5-HTP 75 mg - Natural Supplement Aids Restful Sleep & Neurotransmitter Functions - Brain Health & Function Support - 5-Hydroxytryptophan Supplement - 60 Instant Dissolve Tablets Superior Source Store TabletsFew reviews	$11.08	23d	$22.15	View on Amazon
43	Natrol 5-HTP 100mg, Dietary Supplement Helps Support a Balanced Mood, 90 Time Release Tablets, 22-45 Day Supply Natrol Store Tablets3rd-party tested	$11.48	23d	$17.22	View on Amazon
44	Metabolic Maintenance 5-HTP - Delivers 100 mg 5-Hydroxytryptophan - Supports Serotonin Pathways, a Positive Outlook & Restfuness - 120 Servings - 120 Capsules Metabolic Maintenance Store CapsulesFew reviews	$11.50	60d	$46.00	View on Amazon
45	Nature's Truth 5HTP 200mg Capsules \| 50 Count \| 5 Hydroxytryptophan \| Non-GMO & Gluten Free Supplement Nature's Truth Store Capsules	$11.52	25d	$9.60	View on Amazon
46	Integrative Therapeutics 5-HTP - Supplement that Supports a Healthy Outlook & Restful Sleep* - Vegan, Dairy-Free & Gluten-Free - 60 Capsules (60 Servings) Integrative Therapeutics Store Capsules	$12.00	15d	$24.00	View on Amazon
47	5-HTP Gummies 200mg with SAMe & Vitamin B6 – Blueberry Flavor, 5-HTP Plus S-Adenosyl Methionine for Mood Support, Sleep Support, Relaxation – Non-GMO, Gluten Free, 3rd Party Tested – 60 Gummies FUYUEO Gummies3rd-party tested	$13.00	60d	$25.99	View on Amazon
48	Natrol 5-HTP 100 mg, Fast Dissolve Supplement, Supports a Balanced Mood, Serotonin Production and General Well-Being, 30 Mixed Berry Tablets, Up to a 30 Day Supply Natrol Store Tablets	$13.01	15d	$13.01	View on Amazon
49	Designs for Health 5-HTP 50mg with Vitamin B6 (P-5-P) - 5-HTP Synergy 50 mg Supplement - Serotonin Precursors to Help Support Healthy Mood + Appetite (90 Capsules) Designs for Health Store Capsules	$14.50	23d	$43.49	View on Amazon
50	Natrol 5-HTP 200 mg, Time Release, Support a Balanced Mood, Dietary Supplement Provides Serotonin Production Throughout the Day, 30 Tablets, Up to a 30 Day Supply Natrol Store Tablets	$14.99	30d	$14.99	View on Amazon
51	DR. EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e to Maintain Normal Healthy Sleep and Create a Sense of Wellbeing - 5HTP Supplement with Vitamin B6-60 Vegan Capsules, 30 Servings DR. EMIL NUTRITION Store Capsules	$16.79	30d	$16.79	View on Amazon
52	BeLive 5-HTP Gummies – 2 Pack - 120 Ct I 5HTP Calming Gummies for Heightened Focus, Relaxation & Rest for Adults \| Vegan - Mixed Berries Flavor BeLive Store Gummies	$16.85	46d	$33.70	View on Amazon
53	Irwin Naturals Double Potency 5-HTP Extra - Relaxation & Serotonin Support - 60 Liquid Soft-Gels - 2 Pack Irwin Naturals Store Softgels	$16.95	30d	$33.90	View on Amazon
54	Vital Nutrients 5-HTP 50mg (5-hydroxytryptophan) - Vegan Serotonin Support Supplement* - Sleep and Stress Support - 5HTP and Vitamin B6 - Gluten, Dairy, Soy Free - Non-GMO - 60 Capsules Vital Nutrients Store CapsulesFew reviews	$18.50	15d	$36.99	View on Amazon
55	DR. EMIL NUTRITION 200 MG 5-HTP Plus with SAM-e for Mood, Stress, and Sleep - 5HTP Supplement with Vitamin B6-120 Vegan Capsules, 60 Servings DR. EMIL NUTRITION Store Capsules	$18.80	60d	$37.60	View on Amazon
56	Irwin Naturals Double Potency 5-HTP Extra - Relaxation & Serotonin Support - 60 Liquid Soft-Gels Irwin Naturals Store Softgels	$19.99	15d	$19.99	View on Amazon
57	Pure Encapsulations 5-HTP 50 mg \| 5-Hydroxytryptophan Supplement for Brain, Sleep, Eating Behavior, and Serotonin Support* \| 60 Capsules Pure Encapsulations Store Capsules	$21.25	15d	$42.50	View on Amazon
58	Natrol 5-HTP 200mg Dietary Supplement to Support a Balanced Mood, 60 Time Release Tablets, 60 Day Supply Natrol Store Tablets	$21.66	60d	$43.32	View on Amazon
59	Nature's Way 5-HTP, L-5-Hydroxytryptophan, Helps Make Serotonin to Promote a Positive Outlook*, Vitamin B6, Vitamin C, Griffonia Bean Extract, 30 Tablets (Packaging May Vary) Nature's Way Store Tablets	$21.98	8d	$10.99	View on Amazon
60	Nature's Way 5-HTP L-5-Hydroxytryptophan Vitamin B6 + Vitamin C + Griffonia Bean Extract 30 Count (Pack of 2) Nature's Way Store Tablets	$21.98	15d	$21.98	View on Amazon
61	5-HTP - 200mg 5HTP Supplement (5-Hydroxytryptophan) to Support Mood Plus Sleep, Stress Relief, 60 Capsules - 30 Day Supply, Made in USA Valleywave Labs CapsulesFew reviews	$24.49	30d	$24.49	View on Amazon
62	Vimergy 5-HTP Capsules– Clean Formula Supporting a Healthy Mood, Better Sleep and May Enhance Serotonin Levels.* Kosher and Vegan. – (60 ct.) Vimergy Store Capsules	$25.50	45d	$51.00	View on Amazon
63	THORNE - 5-HTP - Contains Vitamin B6 - Serotonin Support for Sleep & Stress Management* - 5-Hydroxytryptophan Supplement - Third-Party Certified - Gluten, Dairy & Soy-Free - 90 Capsules THORNE Store Capsules3rd-party tested	$26.00	23d	$39.00	View on Amazon
64	Designs for Health 5-HTP 100mg with Vitamin B6 (P-5-P) - 5-HTP Supreme 100 mg Supplement - Serotonin Precursors to Help Support Healthy Mood + Appetite (60 Capsules) Designs for Health Store Capsules	$26.50	30d	$52.99	View on Amazon
65	SmarterVitamins 200mg 5-HTP + Vitamin B6, Extended Time Release, 60 softgels, 30 Servings SmarterVitamins Store Softgels	$29.77	30d	$29.77	View on Amazon
66	Pure Encapsulations 5-HTP 100 mg - Brain Health, Sleep Regulation & Appetite Support* - 5-Hydroxytryptophan - Gluten Free & Non-GMO - 60 Capsules Pure Encapsulations Store Capsules	$30.50	30d	$61.00	View on Amazon

Buying notes for 5-HTP

How to read the label

Check whether the label lists direct 5-HTP, 5-hydroxytryptophan, Griffonia simplicifolia seed extract, or a percentage-standardized extract. Labels reviewed for this update included clear 100-200 mg 5-HTP capsules, powders requiring a milligram scale, and one ambiguous 10% 200 mg 5-HTP line with added vitamin B6 and SAMe.

What changes the real cost

Monthly cost depends on the actual 5-HTP amount, powder versus capsule format, serving count, and whether the product is plain or bundled with mood/sleep cofactors. Bulk powder can be very cheap but adds measurement friction; premium low-dose capsules can be much more expensive.

Common comparison traps

Do not treat a percent-standardized extract line as the same as a plainly listed 5-HTP amount unless the label makes the math clear. For powders, the label-reviewed products explicitly required an accurate milligram scale, so convenience and dosing precision matter alongside price.

Evidence context

5-HTP has emerging evidence for mood and sleep-related outcomes, but much of the clinical literature is older, small, or heterogeneous. TrueServing compares labeled 5-HTP cost at 200 mg/day; serotonin-pathway interactions and safety warnings matter more than chasing the cheapest option.

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