L-Lysine is an essential amino acid that your body can't make on its own. Most people get enough from diet (meat, dairy, legumes), so deficiency is uncommon. The main reason people supplement it is for cold sore (herpes simplex) prevention. The evidence for that use is mixed. Some studies show lysine at 1-3g/day reduces the frequency of outbreaks; others find no effect. A Cochrane review found the overall evidence is limited and mostly low-quality. Lower doses under 1g/day don't appear to do much unless combined with reducing arginine-rich foods in the diet. Higher doses (3g/day) have more consistent results in smaller trials. Lysine is also marketed for anxiety, calcium absorption, and wound healing — these uses have weak or no research backing. If you have a history of cold sores and want to try it, 1g/day is the common starting point, with some protocols going higher during active outbreaks. It's generally well-tolerated but high doses have been linked to gallstones in some people. Products below are ranked by cost at your chosen daily dose.
Read our L-Lysine price comparison article for tips on what to look for when buying l-lysine.
| # | Product | 30-day cost | Supply | Sticker | |
|---|---|---|---|---|---|
| 1 |
NOW Foods Supplements, L-Lysine (L-Lysine Hydrochloride) Powder, Supports Collagen Synthesis*, Amino Acid, 1-Pound
NOW Foods Store
|
$0.58 | 358d | $15.92 | View on Amazon |
| 2 |
Nutricost L-Lysine Powder 1KG (2.2lbs) - Pure L-Lysine, Non-GMO, Gluten Free
Nutricost Store
|
$0.66 | 1000d | $21.95 | View on Amazon |
| 3 |
L-Lysine, 500 mg, 250 Veg Capsules, Now Foods
NOW Foods Store
|
$0.88 | 125d | $7.34 | View on Amazon |
| 4 |
Nutricost L-Lysine Powder 500 Grams - Pure L-Lysine, Non-GMO, Gluten Free
Nutricost Store
|
$0.96 | 500d | $15.95 | View on Amazon |
| 5 |
NutraBio L-Lysine Powder 500g – Essential Amino Acid for Protein Metabolism, Collagen Support, & Immune Health – Pure, Unflavored, Non-GMO, Vegan- 500 Servings
NutraBio Store
|
$1.32 | 500d | $21.99 | View on Amazon |
| 6 |
Best Naturals L-Lysine 500 mg 250 Tablets
Best Naturals Store
|
$1.56 | 125d | $12.99 | View on Amazon |
| 7 |
NOW Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 250 Tablets
NOW Foods Store
|
$1.61 | 125d | $13.39 | View on Amazon |
| 8 |
Source Naturals L-Lysine Free Form -Amino Acid Supplement Supports Energy Formation & Collagen - 200 Capsules
Source Naturals Store
|
$1.80 | 100d | $11.99 | View on Amazon |
| 9 |
Amazing Formulas L-Lysine 500 Mg Amino Acid Supplement | Capsules | Non-GMO | Gluten-Free | Made in USA (1 Pack | 250 Count)
Amazing Nutrition Store
|
$1.80 | 125d | $14.99 | View on Amazon |
| 10 |
NOW Foods Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 100 Count(Pack of 1)
NOW Foods Store
|
$1.83 | 50d | $6.11 | View on Amazon |
| 11 |
Nature's Bounty L-Lysine 1000 Mg Tablets 60 Ea (Pack of 4)
Nature's Bounty Store
|
$2.02 | 240d | $16.19 | View on Amazon |
| 12 |
Source Naturals L-Lysine Free Form -Amino Acid Supplement Supports Energy Formation & Collagen* - 500 mg - 100 Capsules
Source Naturals Store
|
$2.10 | 50d | $7.01 | View on Amazon |
| 13 |
Best Naturals L-Lysine 1000mg 180 Tablets - Double Strength Lysine for stronger immune health & cold sores
Best Naturals Store
|
$2.17 | 180d | $12.99 | View on Amazon |
| 14 |
NOW Foods Supplements, L-Lysine (L-Lysine Monohydrochloride) 500 mg, Amino Acid, 100 Veg Capsules
NOW Foods Store
|
$2.20 | 50d | $7.34 | View on Amazon |
| 15 |
Source Naturals L-Lysine Free Form Powder -Amino Acid Supplement Supports Energy Formation & Collagen* - 100 Grams
Source Naturals Store
|
$2.43 | 76d | $4.86 | View on Amazon |
| 16 |
Amazing Formulas L-Lysine 1000 Mg Amino Acid Supplement | Tablets | Non-GM0 | Gluten-Free | Made in USA (1 Pack | 180 Count)
Amazing Nutrition Store
|
$2.50 | 180d | $14.99 | View on Amazon |
| 17 |
BESTVITE Filler-Free L-Lysine 500mg (240 Veg Capsules) - Vegan - No Stearates or Fillers - Non GMO - Gluten Free - No Dicalcium Phosphate - Amino Acid Supporting Skin, Lip & Immune Health*
BESTVITE Store
|
$2.50 | 120d | $19.99 | View on Amazon |
| 18 |
Now L-Lysine 1000 mg Double Strength,250 Tablets
NOW Foods Store
|
$2.57 | 250d | $21.43 | View on Amazon |
| 19 |
Life Extension L-Lysine, 620 mg, Essential Amino Acid for Healthy nitrogen Balance, Calcium Metabolism, Stress Response & More, Gluten-Free, Non-GMO, Vegetarian, 100 Capsules
Life Extension Store
|
$2.70 | 62d | $9.00 | View on Amazon |
| 20 |
Solgar L-Lysine 1000 mg, 250 Tablets - Enhanced Absorption and Assimilation - Promotes Integrity of Skin and Lips - Collagen Support - Amino Acids - Non-GMO, Vegan, Gluten Free - 250 Servings
Solgar Store
|
$2.76 | 250d | $23.01 | View on Amazon |
| 21 |
Nature Made L-Lysine 1000 mg, Dietary L-Lysine Supplements, 60 Tablets, 60 Day Supply
Nature Made Store
|
$2.87 | 60d | $5.74 | View on Amazon |
| 22 |
365 by Whole Foods Market, L-Lysine 500mg, 100 Count
365 by Whole Foods Market Store
|
$3.00 | 50d | $9.99 | View on Amazon |
| 23 |
Carlson - L-Lysine Powder, Free-Form Amino Acid, 960 mg, Supports Healthy Tissue & Muscle Development, 3.53 oz (100 g)
Carlson Store
|
$3.04 | 80d | $8.42 | View on Amazon |
| 24 |
Solaray L-Lysine 500mg - Pure L Lysine 500 mg Capsules, Essential Amino Acid Supplement for Women and Men, Health Support Pills for Adults and Kids, Free Form, Lab Verified - 120 Vegan Capsules
SOLARAY Store
|
$3.17 | 60d | $12.68 | View on Amazon |
| 25 |
Solaray L-Lysine 500mg, 120 CT
SOLARAY Store
|
$3.17 | 60d | $12.69 | View on Amazon |
| 26 |
Nature's Bounty L-Lysine 1000 mg Tablets 60 ea (Pack of 2)
Nature's Bounty Store
|
$3.30 | 120d | $13.20 | View on Amazon |
| 27 |
Solgar L-Lysine 1000 mg, 100 Tablets - Enhanced Absorption and Assimilation - Promotes Integrity of Skin and Lips - Collagen Support - Amino Acids - Non GMO, Vegan, Gluten Free - 100 Servings
Solgar Store
|
$3.36 | 100d | $11.19 | View on Amazon |
| 28 |
Nutricost L-Lysine 1000mg, 120 Tablets - Gluten Free, Non-GMO, and Vegetarian Friendly
Nutricost Store
|
$3.49 | 120d | $13.95 | View on Amazon |
| 29 |
Nutricost L-Lysine 1000mg, 250 Capsules - 500mg Per Cap, Gluten Free, Non-GMO
Nutricost Store
|
$3.59 | 125d | $14.95 | View on Amazon |
| 30 |
Superior Labs L-Lysine 500 mg Capsules, Pure Non-GMO, Third-Party Tested, No Fillers, Gluten Free, Supports Immune System, Promotes Calcium Absorption, 120 Caps
Superior Labs Store
|
$3.88 | 60d | $15.50 | View on Amazon |
| 31 |
NOW Foods Supplements, (L-Lysine Hydrochloride) 1,000 mg, Double Strength, Amino Acid, 100 Tablets
NOW Foods Store
|
$4.15 | 50d | $6.92 | View on Amazon |
| 32 |
Horbäach L-Lysine Supplement 2000mg | 240 Caplets | Free Form L-Lysine Hydrochloride | Vegetarian, Non-GMO, Gluten Free
Horbäach Store
|
$4.37 | 240d | $17.49 | View on Amazon |
| 33 |
Vitamatic L-Lysine 2000 mg Per Serving | 180 Tablets | Essential Amino Acid Supplement | Non-GMO | Gluten Free | Made in USA
Vitamatic Store
|
$4.66 | 180d | $13.99 | View on Amazon |
| 34 |
Horbäach L-Lysine 1000mg | 100 Coated Caplets | Free Form Dietary Supplement | Essential Amino Acid | Vegetarian, Non-GMO, and Gluten Free Formula
Horbäach Store
|
$4.97 | 50d | $8.29 | View on Amazon |
| 35 |
Dr. Mercola L-Lysine, 90 Capsules 1500 mg L-Lysine, Non-GMO, Gluten Free, Soy Free
Dr. Mercola Store
|
$4.99 | 45d | $14.97 | View on Amazon |
| 36 |
Bluebonnet Nutrition L-Lysine 500mg, for Healthy Immune Function, Supports Collagen Synthesis, Soy-Free, Gluten-Free, Non-GMO, Kosher Certified, Vegan, 100 Capsules
BlueBonnet Store
|
$5.75 | 50d | $19.16 | View on Amazon |
| 37 |
BlueBonnet L-Lysine 1000mg Essential Amino Acids Supplement - Immune & Collagen Support Supplements for Women & Men - Non-GMO, Vegan & Gluten-Free - 1000 mg L Lysine Per Serving - 100 Caplets
BlueBonnet Store
|
$6.47 | 100d | $21.56 | View on Amazon |
| 38 |
Nutricost L-Lysine + Monolaurin (1,200mg) 120 Capsules - L-Lysine HCI, Vegan, GMO-Free, Gluten-Free, 60 Servings
Nutricost Store
|
$6.47 | 36d | $12.95 | View on Amazon |
| 39 |
BIOTICS RESEARCH L Lysine HCI Amino Acid L lysine Supplement Promotes Energy, Boosts Immunity, Stimulates Calcium Absorption 100 Capsules
BIOTICS RESEARCH Store
|
$6.59 | 50d | $21.96 | View on Amazon |
| 40 |
Vimergy L-Lysine – Promotes Healthy Skin, Hair & Nails* – Supports Healthy Metabolism* – Vegan, Non-GMO & Gluten-Free – 90 Capsules
Vimergy Store
|
$6.67 | 45d | $20.00 | View on Amazon |
| 41 |
THORNE - Lysine - Supports Immune, Skin & Bone Health - Promotes Collagen Formation* - L-Lysine Amino Acid Supplement - Third-Party Certified - Gluten, Dairy & Soy-Free - 60 Capsules
THORNE Store
|
$7.50 | 30d | $15.00 | View on Amazon |
| 42 |
Herstat L-Lysine 1500mg Capsules for Lip Health & Immune Support, High Strength 60ct Llysine Pills, Full Month Supply, Lisina Supplement
Herstat Store
|
$8.98 | 90d | $17.96 | View on Amazon |
| 43 |
Pack of 2 L-Lysine 1000mg Gummies for Adults & Kids, Essential Amino Acid Supplement for Lips & Oral Health, Boost Immune & Collagen & Calcium, Sugar-Free, Raspberry Flavor, 120 Count
YUULAI Store
|
$10.00 | 60d | $19.99 | View on Amazon |
| 44 |
VAITE L-Lysine 1000mg Gummies - Supports Skin, Lip, Vegan, Gluten Free, Vitamins for Adults Tissue Health & Immune System, Chewables, Amino Acid Vitamin Supplement & Complex Supplements, Non-GMO
VAITE Store
|
$11.50 | 60d | $22.99 | View on Amazon |
| 45 |
softbear L-Lysine Gummies for Adults & Kids, L Lysine 1000mg Chewable Lysine Supplement for Lips & Oral Health, Immune & Collagen Support, Vegan, Non GMO, Gluten-Free, Raspberry Flavor 120 Count
softbear Store
|
$11.99 | 60d | $23.99 | View on Amazon |
| 46 |
L-Lysine 1000mg Gummies, Lysine Supplement for Adults & Kids, Essential Amino Acid Supplement for Oral & Lips Health, Boost Immune & Calcium & Collagen, Sugar-Free, Strawberry Flavor, 60 Count
MEENCCD Store
|
$12.99 | 30d | $12.99 | View on Amazon |
| 47 |
L-Lysine 1000mg Gummies for Adults & Kids, Essential Amino Acid Supplement for Lips & Oral Health, Boost Immune & Collagen & Calcium, Sugar-Free, Raspberry Flavor, 60 Count
YUULAI Store
|
$12.99 | 30d | $12.99 | View on Amazon |
| 48 |
softbear L-Lysine Gummies for Adults & Kids, L Lysine 1000mg Chewable Lysine Supplement for Lips & Oral Health, Immune & Collagen Support, Vegan, Non GMO, Gluten-Free, Raspberry Flavor 60 Count
softbear Store
|
$13.99 | 30d | $13.99 | View on Amazon |
| 49 |
L-Lysine Gummies 1000mg - L-Lysine Supplements for Kids and Adults - Lip and Cold Sore* Support for Women - Chewable Lysine Gummies with Vitamin B12 - Vegan, Non GMO, Gluten-Free, 120 Counts
Well&Whole Store
|
$17.50 | 30d | $34.99 | View on Amazon |
| 50 |
L-Lysine 1000mg Supplement, Liposomal Lysine Drops, Essential Amino Acid | For adults. Supports immune health, skin & lip health and collagen synthesis. Vegan, Non-GMO, Gluten-free
LAMGINY Store
|
$17.84 | 30d | $17.84 | View on Amazon |
| 51 |
Natural Cure Labs L-Lysine with Monolaurin 600mg 1:1 Ratio, 100 Capsules
Natural Cure Labs Store
|
$17.97 | 30d | $29.95 | View on Amazon |
| 52 |
Vimergy L-Lysine – Promotes Healthy Skin, Hair & Nails* – Supports Healthy Metabolism* – Vegan, Non-GMO & Gluten-Free – 270 Capsules
Vimergy Store
|
$19.25 | 134d | $43.00 | View on Amazon |
| 53 |
XYMOGEN L-Lysine - Essential Amino Acid Supplement - Collagen with Protein Synthesis Support - Aids Healthy Skin, Bone & Tendons - Vegetarian, Dairy-Free & Soy-Free - 90 Capsules
XYMOGEN Store
|
$19.33 | 45d | $28.99 | View on Amazon |
| 54 |
Designs for Health L-Lysine HCL Pills 1500mg - Amino Acid Lysine Hydrochloride Nutritional Supplement for Adults - Immune + Bone Health Support - Vegan + Non-GMO (120 Capsules)
Designs for Health Store
|
$19.49 | 90d | $38.99 | View on Amazon |
| 55 |
MEENCCD L-Lysine 1000mg Gummies, Lysine Supplement for Adults & Kids, Essential Amino Acid Supplement Supports Collagen Formation, Sugar-Free, Raspberry Flavor, 60 Count
MEENCCD Store
|
$19.95 | 30d | $19.95 | View on Amazon |
| 56 |
L-Lysine Gummies 1000mg - L-Lysine Supplements for Kids and Adults - Lip and Cold Sore* Support for Women - Chewable Lysine Gummies with Vitamin B12 - Vegan, Non GMO, Gluten-Free, 60 Counts
Well&Whole Store
|
$19.99 | 15d | $19.99 | View on Amazon |
| 57 |
L-Lysine Gummies 1000mg, Sugar-Free Chewable Lysine with Monolaurin Supplement for Adults & Kids, Lips & Oral Health, Immune & Overall Health, Natural Peach Flavor, 60 Count
Elysx Store
|
$19.99 | 30d | $19.99 | View on Amazon |
| 58 |
Liposomal L-Lysine Gummies 1200mg | High Absorption Immune & Skin Support | Vegan Amino Acid Supplement for Adults & Kids | Lips & Oral, Bone & Collagen Health | Non-GMO, Sugar-Free, 60 Gummies
NEVISS Store
|
$26.14 | 36d | $26.14 | View on Amazon |
| 59 |
L-Lysine Gummies 500/1000mg with Algae Omega 3, Vitamin B2, D3, K2, C for Kids 9+, Teen & Adult, Lysine Supplement Support Immune, Lip & Oral, Collagen Production, Brain, Bone Health, Sugar Free 1Pack
Nextdia Store
|
$29.14 | 30d | $29.14 | View on Amazon |
This is the current ranking surface for L-Lysine. It recalculates cost per month from product price, Supplement Facts active amount, servings per container, and the dose you enter above.
63 active products have enough price and label data to calculate cost before display filters; 59 rows are currently shown in the ranked table. The current review floor for this category is 25+ reviews before any large-category and duplicate/bulk filtering.
At 1000 mg/day, visible products range from $0.58-$29.14/mo with a $3.88/mo median midpoint and a 50.2x low-to-high spread.
Confirm whether the label lists L-Lysine or L-Lysine HCl, and use the Supplement Facts serving amount rather than a title claim. Labels reviewed for this update included tablets, capsules, powders, and gummies with very different serving sizes.
Bulk powders and large-count tablets usually set the low end, while gummies, small bottles, and convenience formats cost more at the same daily lysine target. Capsule count matters because gram-level dosing can require multiple capsules per day.
Do not compare a small gummy serving with a 1,000 mg tablet or powder scoop as if the format were equal. For L-Lysine HCl labels, TrueServing uses the labeled lysine-category amount and does not infer hidden active conversion from the product title.
L-Lysine has low-to-moderate evidence, mostly around cold sore prophylaxis where results are mixed and dose-dependent. TrueServing compares labeled cost at 1,000 mg/day and does not rank immune or skin claims beyond the label data.
TrueServing participates in the Amazon Associates program. We may earn a commission when you purchase through our links at no extra cost to you. Prices are updated regularly but may vary.