L-Lysine is an essential amino acid that your body can't make on its own. Most people get enough from diet (meat, dairy, legumes), so deficiency is uncommon. The main reason people supplement it is for cold sore (herpes simplex) prevention. The evidence for that use is mixed. Some studies show lysine at 1-3g/day reduces the frequency of outbreaks; others find no effect. A Cochrane review found the overall evidence is limited and mostly low-quality. Lower doses under 1g/day don't appear to do much unless combined with reducing arginine-rich foods in the diet. Higher doses (3g/day) have more consistent results in smaller trials. Lysine is also marketed for anxiety, calcium absorption, and wound healing — these uses have weak or no research backing. If you have a history of cold sores and want to try it, 1g/day is the common starting point, with some protocols going higher during active outbreaks. It's generally well-tolerated but high doses have been linked to gallstones in some people. Products below are ranked by cost at your chosen daily dose.
| # | Product | 30-day cost | Supply | Sticker | |
|---|---|---|---|---|---|
| 1 |
NOW Foods Supplements, L-Lysine (L-Lysine Hydrochloride) Powder, Supports Collagen Synthesis*, Amino Acid, 1-Pound
NOW Foods Store
|
$0.58 | 358d | $15.92 | View on Amazon |
| 2 |
Nutricost L-Lysine Powder 1KG (2.2lbs) - Pure L-Lysine, Non-GMO, Gluten Free
Nutricost Store
|
$0.66 | 1000d | $21.95 | View on Amazon |
| 3 |
Best Naturals L-Lysine 500 mg 250 Tablets
Best Naturals Store
|
$1.20 | 125d | $9.99 | View on Amazon |
| 4 |
NutraBio L-Lysine Powder 500g – Essential Amino Acid for Protein Metabolism, Collagen Support, & Immune Health – Pure, Unflavored, Non-GMO, Vegan- 500 Servings
NutraBio Store
|
$1.32 | 500d | $21.99 | View on Amazon |
| 5 |
Source Naturals L-Lysine Free Form -Amino Acid Supplement Supports Energy Formation & Collagen - 200 Capsules
Source Naturals Store
|
$1.50 | 100d | $10.00 | View on Amazon |
| 6 |
NOW Supplements, L-Lysine (L-Lysine Hydrochloride) 500 mg, Amino Acid, 250 Tablets
NOW Foods Store
|
$1.52 | 125d | $12.70 | View on Amazon |
| 7 |
Amazing Formulas L-Lysine 500 Mg Amino Acid Supplement | Capsules | Non-GMO | Gluten-Free | Made in USA (1 Pack | 250 Count)
Amazing Nutrition Store
|
$1.65 | 125d | $13.79 | View on Amazon |
| 8 |
Best Naturals L-Lysine 1000mg 180 Tablets - Double Strength Lysine for stronger immune health & cold sores
Best Naturals Store
|
$1.67 | 180d | $9.99 | View on Amazon |
| 9 |
L-Lysine, 500 mg, 250 Veg Capsules, Now Foods
NOW Foods Store
|
$2.06 | 125d | $17.14 | View on Amazon |
| 10 |
NOW Foods Supplements, L-Lysine (L-Lysine Hydrochloride) 1,000 mg, Double Strength, Amino Acid, 250 Tablets
NOW Foods Store
|
$2.08 | 250d | $17.30 | View on Amazon |
| 11 |
Source Naturals L-Lysine Free Form -Amino Acid Supplement Supports Energy Formation & Collagen - 100 Capsules
Source Naturals Store
|
$2.10 | 50d | $7.01 | View on Amazon |
| 12 |
NOW Foods Supplements, L-Lysine (L-Lysine Monohydrochloride) 500 mg, Amino Acid, 100 Veg Capsules
NOW Foods Store
|
$2.10 | 50d | $7.00 | View on Amazon |
| 13 |
Source Naturals L-Lysine Free Form Powder -Amino Acid Supplement Supports Energy Formation & Collagen* - 100 Grams
Source Naturals Store
|
$2.43 | 76d | $4.86 | View on Amazon |
| 14 |
Amazing Formulas L-Lysine 1000 Mg Amino Acid Supplement | Tablets | Non-GM0 | Gluten-Free | Made in USA (1 Pack | 180 Count)
Amazing Nutrition Store
|
$2.50 | 180d | $14.99 | View on Amazon |
| 15 |
365 by Whole Foods Market, L-Lysine 500mg, 100 Count
365 by Whole Foods Market Store
|
$2.63 | 50d | $8.78 | View on Amazon |
| 16 |
Nutricost L-Lysine 1000mg Per Serving, 250 Servings, 500 Capsules - Gluten Free, Non-GMO, 500mg Per Capsule
Nutricost Store
|
$2.63 | 250d | $21.95 | View on Amazon |
| 17 |
Life Extension L-Lysine, 620 mg, Essential Amino Acid for Healthy nitrogen Balance, Calcium Metabolism, Stress Response & More, Gluten-Free, Non-GMO, Vegetarian, 100 Capsules
Life Extension Store
|
$2.70 | 62d | $9.00 | View on Amazon |
| 18 |
Solgar L-Lysine 1000 mg, 250 Tablets - Enhanced Absorption and Assimilation - Promotes Integrity of Skin and Lips - Collagen Support - Amino Acids - Non-GMO, Vegan, Gluten Free - 250 Servings
Solgar Store
|
$2.76 | 250d | $23.01 | View on Amazon |
| 19 |
SOLARAY L Lysine 500 mg Capsules - Free-Form Essential Amino Acids Supplement - Powerful Wellness Support with L-Lysine Amino Acid - Lab Verified, 60-Day Guarantee, 120 Servings, 120 VegCaps
SOLARAY Store
|
$3.25 | 60d | $12.98 | View on Amazon |
| 20 |
Solgar L-Lysine 1000 mg, 100 Tablets - Enhanced Absorption and Assimilation - Promotes Integrity of Skin and Lips - Collagen Support - Amino Acids - Non GMO, Vegan, Gluten Free - 100 Servings
Solgar Store
|
$3.36 | 100d | $11.19 | View on Amazon |
| 21 |
Nutricost L-Lysine 1000mg, 250 Capsules - 500mg Per Cap, Gluten Free, Non-GMO
Nutricost Store
|
$3.59 | 125d | $14.95 | View on Amazon |
| 22 |
NOW Foods Supplements, (L-Lysine Hydrochloride) 1,000 mg, Double Strength, Amino Acid, 100 Tablets
NOW Foods Store
|
$4.15 | 50d | $6.92 | View on Amazon |
| 23 |
Nature Made L-Lysine 1000 mg, Dietary L-Lysine Supplements, 60 Tablets, 60 Day Supply
Nature Made Store
|
$4.24 | 60d | $8.48 | View on Amazon |
| 24 |
Horbäach L-Lysine Supplement 2000mg | 240 Caplets | Free Form L-Lysine Hydrochloride | Vegetarian, Non-GMO, Gluten Free
Horbäach Store
|
$4.37 | 240d | $17.49 | View on Amazon |
| 25 |
Horbäach L-Lysine 1000mg | 100 Coated Caplets | Free Form Dietary Supplement | Essential Amino Acid | Vegetarian, Non-GMO, and Gluten Free Formula
Horbäach Store
|
$4.79 | 50d | $7.99 | View on Amazon |
| 26 |
Superior Labs L-Lysine 500 mg Capsules, Pure Non-GMO, Third-Party Tested, No Fillers, Gluten Free, Supports Immune System, Promotes Calcium Absorption, 120 Caps
Superior Labs Store
|
$5.49 | 60d | $21.95 | View on Amazon |
| 27 |
BlueBonnet L-Lysine 1000mg Essential Amino Acids Supplement - Immune & Collagen Support Supplements for Women & Men - Non-GMO, Vegan & Gluten-Free - 1000 mg L Lysine Per Serving - 100 Caplets
BlueBonnet Store
|
$6.47 | 100d | $21.56 | View on Amazon |
| 28 |
Nutricost L-Lysine + Monolaurin (1,200mg) 120 Capsules - L-Lysine HCI, Vegan, GMO-Free, Gluten-Free, 60 Servings
Nutricost Store
|
$6.47 | 36d | $12.95 | View on Amazon |
| 29 |
Vimergy L-Lysine – Promotes Healthy Skin, Hair & Nails* – Supports Healthy Metabolism* – Vegan, Non-GMO & Gluten-Free – 90 Capsules
Vimergy Store
|
$6.67 | 45d | $20.00 | View on Amazon |
| 30 |
L-Lysine 1000mg Gummies for Adults & Kids, Essential Amino Acid Supplement for Lips & Oral Health, Boost Immune & Collagen & Calcium, Sugar-Free, Raspberry Flavor, 60 Count
YUULAI Store
|
$9.99 | 30d | $9.99 | View on Amazon |
| 31 |
VAITE L-Lysine 1000mg Gummies - Supports Skin, Lip, Vegan, Gluten Free, Vitamins for Adults Tissue Health & Immune System, Chewables, Amino Acid Vitamin Supplement & Complex Supplements, Non-GMO
VAITE Store
|
$11.50 | 60d | $22.99 | View on Amazon |
| 32 |
softbear L-Lysine Gummies for Adults & Kids, L Lysine 1000mg Chewable Lysine Supplement for Lips & Oral Health, Immune & Collagen Support, Vegan, Non GMO, Gluten-Free, Raspberry Flavor 120 Count
softbear Store
|
$13.00 | 60d | $25.99 | View on Amazon |
| 33 |
MEENCCD 2 Pack L-Lysine 1000mg Gummies, Lysine Supplement for Adults & Kids, Essential Amino Acid Supplement Supports Collagen Formation, Sugar-Free, Raspberry Flavor, 120 Count
MEENCCD Store
|
$14.98 | 60d | $29.95 | View on Amazon |
| 34 |
L-Lysine Gummies 1000mg - L-Lysine Supplements for Kids and Adults - Lip and Cold Sore* Support for Women - Chewable Lysine Gummies with Vitamin B12 - Vegan, Non GMO, Gluten-Free, 120 Counts
Well&Whole Store
|
$17.50 | 30d | $34.99 | View on Amazon |
| 35 |
Natural Cure Labs L-Lysine with Monolaurin 600mg 1:1 Ratio, 100 Capsules
Natural Cure Labs Store
|
$17.97 | 30d | $29.95 | View on Amazon |
| 36 |
Designs for Health L-Lysine HCL Pills 1500mg - Amino Acid Lysine Hydrochloride Nutritional Supplement for Adults - Immune + Bone Health Support - Vegan + Non-GMO (120 Capsules)
Designs for Health Store
|
$19.00 | 90d | $37.99 | View on Amazon |
| 37 |
MEENCCD L-Lysine 1000mg Gummies, Lysine Supplement for Adults & Kids, Essential Amino Acid Supplement Supports Collagen Formation, Sugar-Free, Raspberry Flavor, 60 Count
MEENCCD Store
|
$19.95 | 30d | $19.95 | View on Amazon |
| 38 |
L-Lysine Gummies 1000mg, Sugar-Free Chewable Lysine with Monolaurin Supplement for Adults & Kids, Lips & Oral Health, Immune & Overall Health, Natural Peach Flavor, 60 Count
Elysx Store
|
$19.99 | 30d | $19.99 | View on Amazon |
| 39 |
L-Lysine Gummies 1000mg - L-Lysine Supplements for Kids and Adults - Lip and Cold Sore* Support for Women - Chewable Lysine Gummies with Vitamin B12 - Vegan, Non GMO, Gluten-Free, 60 Counts
Well&Whole Store
|
$19.99 | 15d | $19.99 | View on Amazon |
| 40 |
Liposomal L-Lysine Gummies 1200mg | High Absorption Immune & Skin Support | Vegan Amino Acid Supplement for Adults & Kids | Lips & Oral, Bone & Collagen Health | Non-GMO, Sugar-Free, 60 Gummies
NEVISS Store
|
$26.14 | 36d | $26.14 | View on Amazon |
| 41 |
L-Lysine Gummies 500/1000mg with Algae Omega 3, Vitamin B2, D3, K2, C for Kids 9+, Teen & Adult, Lysine Supplement Support Immune, Lip & Oral, Collagen Production, Brain, Bone Health, Sugar Free 1Pack
Nextdia Store
|
$29.14 | 30d | $29.14 | View on Amazon |
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