NAC, short for N-Acetyl Cysteine, is a cysteine donor used to support Glutathione production, antioxidant defense, respiratory function, and liver health. It is one of the more evidence-backed supplement categories on TrueServing, with clinical use in acetaminophen toxicity and a long history of study around mucus clearance, oxidative stress, and glutathione support.
This comparison ranks NAC products by estimated cost per month at 600 mg/day. NAC is sold as capsules, tablets, powders, gummies, softgels, and specialty blends. The ingredient itself is usually easy to identify on the Supplement Facts panel, but the price spread is wide because powders, capsules, gummies, and multi-ingredient products are priced very differently at the same NAC dose.
Prices as of June 3, 2026. Prices update daily; this page updates monthly. For current prices and full interactive filters, see the NAC (N-Acetyl Cysteine) compare page.
| Rank | Brand | Product | Form | Cost per month | Price |
|---|---|---|---|---|---|
| 1 | BulkSupplements | BulkSupplements.com NAC Powder - N-Acetyl Cysteine 600mg, N… | Powder | $1.04 | $28.97 |
| 2 | PURE ORIGINAL INGREDIENTS | PURE ORIGINAL INGREDIENTS NAC Powder, 12.8 oz, N-Acetyl L-C… | Powder | $1.12 | $22.49 |
| 3 | Nutricost | Nutricost N-Acetyl L-Cysteine (NAC) Powder 500 Grams - Vega… | Powder | $1.41 | $39.28 |
| 4 | NOW Foods | Now Supplements, NAC (N-Acetyl Cysteine) 600 mg Pure Powder… | Powder | $2.78 | $17.40 |
| 5 | NutraBio | NutraBio N-Acetyl Cysteine Supplement (NAC) - 150 Grams Pow… | Powder | $2.88 | $23.99 |
| Rank | Brand | Product | Form | Cost per month | Price |
|---|---|---|---|---|---|
| 1 | Source Naturals | Source Naturals N-Acetyl Cysteine Antioxidant Support 1000… | Tablets | $1.59 | $5.30 |
| 2 | BulkSupplements | BulkSupplements.com N-Acetyl L-Cysteine Capsules - N-Acetyl… | Capsules | $1.75 | $20.97 |
| 3 | Horbäach | Horbäach NAC N-Acetyl Cysteine Supplement 1200mg | 250 Pow… | Capsules | $2.39 | $19.89 |
| 4 | Toniiq | Toniiq 1300mg NAC - 4 Month Supply - Min. 98%+ Tested Purit… | Capsules | $2.42 | $20.98 |
| 5 | Best Naturals | Best Naturals NAC - N Acetyl Cysteine 600 mg 120 Capsules -… | Capsules | $2.50 | $9.99 |
See all NAC products with full filter and sort options ->
Look for N-Acetyl Cysteine or N-Acetyl L-Cysteine. NAC labels commonly use either the abbreviation "NAC" or the full name "N-Acetyl Cysteine" / "N-Acetyl L-Cysteine." Those names refer to the same core ingredient for shopping purposes. The cleanest labels state the NAC amount directly, usually 600 mg, 1,000 mg, or 500 mg per capsule, tablet, or powder serving.
Check the serving size, not just the bottle count. A 120-capsule bottle can last 120 days if the serving is one capsule, but only 60 days if the suggested serving is two capsules. Powders can look expensive upfront but often contain hundreds or even more than a thousand 600 mg servings.
Powder is usually the cheapest format by a lot. NAC powder can be extremely inexpensive per 600 mg serving, especially in large pouches. The tradeoff is convenience: you need to measure a small amount, tolerate the sulfur-like taste, and keep the powder dry. Capsules and tablets are easier to use but usually cost more per month.
Be careful with gummies and specialty blends. Gummies, hydrogen tablets, antioxidant blends, and "immune support" stacks may include only a small amount of NAC per serving. They can be useful if you specifically want the combined formula, but they are usually poor value if your goal is simply to buy NAC.
Selenium is common, but not required. Some NAC products include selenium, often 25 mcg per serving. That can make sense because selenium is involved in antioxidant enzyme systems, but it is not necessary for a NAC product to be valid. If you already take a multivitamin or a selenium supplement, check your total selenium intake before choosing a NAC+selenium formula.
Quality signals matter more than fancy claims. Third-party testing, GMP manufacturing, non-GMO, vegan capsules, and allergen disclosures are useful signals. They are more meaningful than vague claims about detox, immunity, or cellular health. NAC is already a well-defined ingredient, so the best labels make the dose and serving count easy to verify.
Avoid proprietary blends when you want a precise NAC dose. A label that lists NAC directly is easier to compare than a product that buries it inside a blend. If NAC is one ingredient among many and the amount is low or unclear, the product should not be treated as equivalent to a simple 600 mg NAC capsule or powder serving.
NAC is often used as a precursor to glutathione rather than as a direct glutathione replacement. That distinction matters for both price and expectations. NAC supplies cysteine, one of the amino acids needed to make glutathione, while glutathione supplements provide glutathione itself. If your goal is general antioxidant support, NAC is usually the cheaper and more studied starting point. Direct glutathione products can be relevant for specific use cases, but they are a different category with different pricing.
NAC has stronger evidence than many supplement categories, especially for respiratory mucus clearance, liver protection, and glutathione support. This page compares products at 600 mg/day, while typical supplemental use often ranges from 600-1800 mg/day depending on the goal. NAC can interact with nitroglycerin and may not be appropriate for everyone, especially people with asthma, bleeding risks, upcoming surgery, or complex medication regimens. It is also a medical treatment in acetaminophen poisoning, which should never be self-managed with consumer supplements.