Glycine is a simple amino acid your body uses to build proteins and support normal nervous-system signaling. People most commonly take it as a sleep supplement (often 3 g shortly before bed) and sometimes as a basic amino-acid add-on for connective tissue support because glycine is abundant in collagen and gelatin.
When you shop for glycine, the main thing to know is that format drives the price spread. Bulk powders can be extremely cheap per 3 g serving, while single-serve sticks, flavored "sleep" powders, and some premium brands can cost dramatically more for the same amount of glycine. The tables below use 3 g/day as a consistent comparison point so different products can be compared on the same monthly-cost basis.
Prices as of June 3, 2026. Prices update daily; this page updates monthly. For current prices and full interactive filters, see the Glycine compare page.
| Rank | Brand | Product | Form | Cost per month | Price |
|---|---|---|---|---|---|
| 1 | TradeKing | Glycine Powder (2 lbs) - Promotes Restful Sleep, Muscle Ene… | Powder | $1.91 | $23.95 |
| 2 | Carlson | Carlson - Glycine Powder, 2000 mg Glycine, Amino Acid Powde… | Powder | $1.91 | $10.63 |
| 3 | PURE ORIGINAL INGREDIENTS | Pure Original Ingredients Glycine Powder (2lb) Non-GMO, Non… | Powder | $2.58 | $25.99 |
| 4 | Micro Ingredients | Micro Ingredients Glycine Powder, 1KG (2.2 Pounds), Glycine… | Powder | $2.61 | $28.99 |
| 5 | Vitamatic | Vitamatic Glycine Powder – 3,000 mg Per Serving, Free-Form… | Powder | $3.25 | $17.99 |
| Rank | Brand | Product | Form | Cost per month | Price |
|---|---|---|---|---|---|
| 1 | Vitamatic | Vitamatic Glycine Supplement, 2000mg Per Serving, 300 Count… | Capsules | $5.40 | $17.99 |
| 2 | BulkSupplements | BulkSupplements.com Glycine Capsules - Glycine Supplements,… | Capsules | $6.99 | $20.97 |
| 3 | NOW Foods | Now Supplements, Glycine 1,000 mg Free-Form, Neurotransmitt… | Capsules | $8.89 | $24.59 |
| 4 | Life Extension | Life Extension Glycine, 1000 mg, Amino Acid that Promotes H… | Capsules | $10.80 | $12.00 |
| 5 | Nutricost | Nutricost L-Glycine 1000mg, 120 Capsules, Vegetarian, Non-G… | Capsules | $11.96 | $15.95 |
See all Glycine products with full filter and sort options ->
1) Decide on form first: powder value vs capsule convenience. Glycine is straightforward to make as a bulk powder, which is why powders often dominate value. Capsules are simpler to use (no measuring, easy travel), but reaching 3 g/day can mean multiple capsules per serving depending on the label. If you care about cost, start by checking powder options; if you care about routine simplicity, plan for a higher monthly cost with capsules or sticks.
2) Check the serving size math on Supplement Facts (especially for capsules). Many capsule labels list 1,000 mg per serving, but the serving may be 3 capsules (not 1). That matters for both convenience and how long the bottle lasts. Before buying, confirm:
3) Make sure you're buying glycine (not "magnesium glycinate," TMG/betaine, or a blend). Glycine is the amino acid. Magnesium glycinate is magnesium bound to glycine, and it's priced and dosed completely differently (if you want that form of magnesium, see Magnesium Glycinate). TMG/betaine (trimethylglycine) is also a different ingredient despite the name similarity. "Sleep blends" and "amino complexes" can be good products, but they're not a clean way to compare glycine value.
4) For powder, look for measurement clarity (and consider a scale). A good label makes it easy to take a repeatable 3 g serving (for example, a serving size stated in grams and a consistent scoop description). If a product leans on "approximate" teaspoon measures or vague scoop guidance, dosing can drift. If precision matters to you, using a small kitchen scale is the simplest fix.
5) Watch for convenience premiums: sticks and flavored powders can cost a lot more. Single-serve packets and flavored drink mixes are convenient, but you're often paying for packaging and flavor systems more than the glycine itself. If you're choosing a stick product for travel or because you dislike the taste of plain glycine, treat it as a convenience choice - not a better form of glycine.
6) Don't overpay for "extra" claims that don't change the glycine amount. Many glycine products are essentially the same ingredient. After you've confirmed you're getting 3 g/day of glycine, higher prices are usually driven by brand positioning, flavoring, stick packs, or capsule convenience. If two products deliver the same glycine dose and you tolerate both, the cheaper one is often the rational choice.
7) Set expectations and timing: evidence is strongest for sleep at bedtime dosing. The best-supported use case for supplemental glycine is sleep-related outcomes in small human studies, commonly taken before bed. If you're buying glycine for broader claims (metabolic health, longevity, "detox," or collagen-related benefits), be aware the evidence is less settled - and it may not be worth paying a premium format price for those goals.
Evidence for glycine is moderate. Human evidence is most consistent for sleep quality and next-day fatigue measures in small trials using bedtime dosing around 3 g. Evidence is less established for broader claims such as longevity, metabolic outcomes, or skin/joint effects from standalone glycine supplementation.
Glycine is generally well tolerated for most people. Some people experience GI discomfort, headache, or next-morning grogginess at higher doses. If you are pregnant or breastfeeding, managing a medical condition, or taking prescription medications, consider professional guidance before starting.