Phosphatidylserine (often abbreviated PS) is a phospholipid — a fat molecule that's a building block of every cell membrane in your body, with especially high concentrations in brain cells. People take it most often to support memory and thinking as they get older, and some athletes use higher doses to blunt the cortisol spike after hard training. Most studies that found cognitive benefits used 100 mg three times a day, for a total of 300 mg/day. Higher doses up to 800 mg/day have been used in research on stress and exercise recovery.
This page compares phosphatidylserine products by cost per month at a reference dose of 300 mg/day. Rankings are based on the amount of phosphatidylserine listed on the Supplement Facts label divided into the product's price. One product per brand in each table; lowest cost per month wins.
Prices as of May 2, 2026. Prices update daily; this page updates monthly. For current prices and full interactive filters, see the Phosphatidylserine compare page.
| Rank | Brand | Product | Form | Cost per month | Price |
|---|---|---|---|---|---|
| 1 | TrySafe | Phosphatidylserine Supplement 300mg per Serving Memory and… | Capsules | $9.99 | $9.99 |
| 2 | WONDER FAMILY | Phosphatidylserine 600 mg with L-Carnosine 500 mg + B6, B12… | Capsules | $9.99 | $19.99 |
| 3 | ML Naturals | ML Naturals Phosphatidyl Serine 200mg (Per Serving) – 120 V… | Capsules | $11.24 | $14.99 |
| 4 | Nutricost | Nutricost Phosphatidylserine 400mg, 120 Capsules - Soy Free… | Capsules | $17.96 | $23.95 |
| 5 | Number One Nutrition | Number One Nutrition Premium Phosphatidylserine 400mg, Deri… | Capsules | $20.96 | $27.95 |
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Standardization and what the label mg actually means: PS is extracted from phospholipid complexes — usually soy or sunflower lecithin. Some labels list the complex weight alongside a standardization percentage: "Phosphatidylserine 500 mg (Standardized to 20%)" means only 100 mg is actual PS. Others list just the PS amount with no percentage, claiming that value as their PS content. The difference is enormous for price comparison — a product at 500 mg complex with 20% standardization delivers the same PS as one listing 100 mg, but looks five times cheaper if you read the headline number. Most products on the market list PS without a standardization percentage, and those labels are claiming that amount as actual PS. TrueServing applies the standardization math when a percentage is disclosed on the label, so rankings reflect actual PS content.
Source: soy vs. sunflower lecithin: PS is extracted from lecithin, and most products start from either soy or sunflower. The finished phosphatidylserine molecule is chemically the same regardless of source, so cognitive effects should be comparable. Sunflower-derived PS costs more to produce and is usually labeled as soy-free or non-GMO — useful if you avoid soy, but you're paying a premium for the source rather than for more active ingredient.
Branded ingredients (Sharp-PS, Sharp-PS Green): Some products use trademarked PS ingredients like Sharp-PS or Sharp-PS Green that are tested for purity and standardization. These tend to cost more than generic PS at the same milligram dose. A branded ingredient doesn't deliver more PS per milligram — it's a quality assurance signal, not a potency multiplier.
PS combined with omega-3 (DHA/EPA): A subset of products bundle fish oil or krill oil to deliver PS attached to omega-3 fatty acids, sometimes marketed as "PS-DHA" or similar. These cost noticeably more per milligram of PS because you're paying for two ingredients in one capsule. If you already take Fish Oil, pairing a standalone PS product with your existing omega-3 is usually cheaper than buying a combo.
Dose per serving and timing: PS softgels range from 100 mg to 500 mg of PS each, and most reach the studied 300 mg/day with one to three softgels. Compare cost per month at the same total daily dose, not per softgel — a "100 mg" bottle that's cheaper per softgel can still cost more per month than a 300 mg product taken once a day. Some users find PS taken late at night can interfere with sleep at higher doses, so split dosing across the day is a reasonable starting pattern.
Phosphatidylserine has moderate evidence for supporting memory and cognitive function in older adults, and the FDA has authorized two qualified health claims related to age-related cognitive function — meaning the agency reviewed the science but found it limited rather than conclusive. Effects in healthy younger adults are less consistent. For exercise recovery and cortisol blunting, evidence is moderate at higher doses (around 600 mg/day for 10 or more days). Most cognitive studies use 100 mg three times daily for a total of 300 mg/day. PS is generally well tolerated; reported side effects include mild stomach upset and, occasionally, insomnia at higher doses taken late in the day. Because PS may have mild blood-thinning effects, anyone taking anticoagulants such as warfarin or heparin, or antiplatelet drugs, should talk to a clinician before supplementing. This page is informational and not medical advice.